Endocrine functions of bone in mineral metabolism regulation

J Clin Invest. 2008 Dec;118(12):3820-8. doi: 10.1172/JCI36479. Epub 2008 Dec 1.


Given the dramatic increase in skeletal size during growth, the need to preserve skeletal mass during adulthood, and the large capacity of bone to store calcium and phosphate, juxtaposed with the essential role of phosphate in energy metabolism and the adverse effects of hyperphosphatemia, it is not surprising that a complex systems biology has evolved that permits cross-talk between bone and other organs to adjust phosphate balance and bone mineralization in response to changing physiological requirements. This review examines the newly discovered signaling pathways involved in the endocrine functions of bone, such as those mediated by the phosphaturic and 1,25(OH)2D-regulating hormone FGF23, and the broader systemic effects associated with abnormalities of calcium and phosphate homeostasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Bone Density
  • Bone and Bones / metabolism*
  • Calcitriol / metabolism*
  • Calcium / metabolism
  • Energy Metabolism*
  • Fibroblast Growth Factors / physiology*
  • Homeostasis*
  • Humans
  • Hyperphosphatemia / metabolism
  • Phosphates / metabolism


  • Phosphates
  • Fibroblast Growth Factors
  • fibroblast growth factor 23
  • Calcitriol
  • Calcium