A 59-year-old man underwent a whole-body PET/CT scan to evaluate the metabolic activity of a nodule in the upper lobe of the left lung seen on CT. Slightly increased peripheral activity with a large hypometabolic region centrally, a so-called doughnut sign, was seen in the right lobe of the liver. After the diagnosis of a hydatid cyst of the liver, the patient underwent surgery. This case demonstrates a hydatid cyst that caused increased F-18 FDG uptake as a doughnut pattern.