Abstract
In organ transplantation, blood borne cells and macromolecules (e.g., antibodies) of the host immune system are brought into direct contact with the endothelial cell lining of graft vessels. In this location, graft endothelial cells play several roles in allograft rejection, including the initiation of rejection responses by presentation of alloantigen to circulating T cells; the development of inflammation and thrombosis; and as targets of injury and agents of repair.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigen Presentation / immunology
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Antigen-Presenting Cells / immunology
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Cells, Cultured
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Complement System Proteins / immunology
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Endothelium, Vascular / cytology
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Endothelium, Vascular / immunology
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Endothelium, Vascular / pathology*
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Graft Rejection / etiology*
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Graft Rejection / immunology
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Graft Rejection / pathology*
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HLA Antigens / immunology
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Histocompatibility Antigens Class II / immunology
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Humans
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Immunologic Memory
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Major Histocompatibility Complex
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Mice
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Organ Transplantation / pathology*
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Species Specificity
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T-Lymphocytes / immunology
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T-Lymphocytes / pathology
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T-Lymphocytes, Cytotoxic / immunology
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T-Lymphocytes, Cytotoxic / pathology
Substances
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HLA Antigens
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Histocompatibility Antigens Class II
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Complement System Proteins