Clipping of very large or giant unruptured intracranial aneurysms in the anterior circulation: an outcome study

J Neurosurg. 2008 Dec;109(6):1012-8. doi: 10.3171/JNS.2008.109.12.1012.


Object: Patients with very large or giant unruptured intracranial aneurysms present with ischemic stroke and progressive disability. The aneurysm rupture risk in these patients is extreme-up to 50% in 5 years. In this study the authors investigated the outcome of surgical treatment for these very large aneurysms in the anterior circulation. METHODS Clinical data on 62 patients who underwent surgery for unruptured aneurysms (20-60 mm) between 1998 and 2006 were reviewed.

Results: Complete aneurysm occlusion (100%) was achieved in 90% of cases, near complete occlusion (90-99%) in 5%. The surgical risk in patients younger than 50 years of age was 8% (Glasgow Outcome Scale score of 1 or 3 within 1 year after surgery). In older patients, the risk increased with advancing age.

Conclusions: The treatment of very large or giant unruptured intracranial aneurysms is hazardous and complex and thus best performed only at major cerebrovascular centers with an experienced team of neurosurgeons, interventional neuroradiologists, neurologists, and neuroanesthesiologists. Surgery, with acceptable risks and excellent occlusion rates, is typically the treatment of choice in patients younger than 50 years of age. In older patients, the benefits of endovascular treatment versus surgery versus no treatment must be carefully weighed individually. Minimizing temporary occlusion and the consequent use of intraoperative angiography may help reduce surgical complications.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aneurysm, Ruptured / prevention & control
  • Cerebral Angiography
  • Female
  • Humans
  • Intracranial Aneurysm / surgery*
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Neurosurgical Procedures / methods*
  • Retrospective Studies
  • Risk Factors
  • Surgical Instruments*
  • Treatment Outcome
  • Young Adult