Constant ambient temperature of 24 degrees C significantly reduces FDG uptake by brown adipose tissue in children scanned during the winter

Eur J Nucl Med Mol Imaging. 2009 Apr;36(4):602-6. doi: 10.1007/s00259-008-0983-y. Epub 2008 Nov 27.


Purpose: The aim of this study was to determine if warming patients prior to and during (18)F-FDG uptake by controlling the room temperature could decrease uptake by brown adipose tissue (BAT).

Methods: A group of 40 children underwent (18)F-FDG PET after being kept in the injection room at a constant temperature of 24 degrees C for half an hour before and 1 hour after intravenous tracer administration. The rate of uptake by BAT in this group was compared to the uptake in a control group of 45 patients who underwent PET when the injection room temperature was 21 degrees C.

Results: Uptake by BAT occurred in 5% of studies in the temperature-controlled room compared to 31% of studies performed when the injection room temperature was 21 degrees C (p<0.002).

Conclusion: Maintaining room temperature at a constant 24 degrees C, half an hour prior to and during the period of FDG uptake significantly decreases accumulation of FDG in BAT in children.

MeSH terms

  • Adipose Tissue, Brown / metabolism*
  • Case-Control Studies
  • Child
  • Child, Preschool
  • False Positive Reactions
  • Female
  • Fluorodeoxyglucose F18 / pharmacology*
  • Humans
  • Infant
  • Male
  • Positron-Emission Tomography / methods*
  • Radiopharmaceuticals / pharmacology*
  • Retrospective Studies
  • Seasons
  • Temperature


  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18