From phagocyte diversity and activation to probiotics: back to Metchnikoff

Eur J Immunol. 2008 Dec;38(12):3269-73. doi: 10.1002/eji.200838918.


In this issue of the European Journal of Immunology, Siamon Gordon gives a detailed account of Metchnikoff's life and his achievements (Eur. J. Immunol. 2008. 38: 3257-3264). Looking back at the roots of innate immunity stimulates reflections on open issues in the field. Here, I give a personal view of some of these issues, including myeloid-derived suppressor cells, macrophage polarization and adaptive responses of mononuclear phagocytes.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Biological / immunology
  • Animals
  • Cell Differentiation / immunology
  • Humans
  • Macrophages / cytology
  • Macrophages / immunology
  • Myeloid Cells / cytology
  • Myeloid Cells / immunology
  • Phagocytes / drug effects*
  • Phagocytes / immunology*
  • Probiotics / pharmacology*