Oral implants placed in bone defects treated with Bio-Oss, Ostim-Paste or PerioGlas: an experimental study in the rabbit tibiae

Clin Oral Implants Res. 2008 Dec;19(12):1246-53. doi: 10.1111/j.1600-0501.2008.01584.x.


Objectives: To compare the histological features of bone filled with Bio-Oss, Ostim-Paste or PerioGlas placed in defects in the rabbit tibiae by evaluating bone tissue composition and the integration of titanium implants placed in the grafted bone.

Material and methods: Two cylindrical bone defects, about 4 mm in diameter and 6 mm in depth, were created in the tibiae of 10 rabbits. The defects were filled with either Bio-Oss, PerioGlas, Ostim-Paste or left untreated, and covered with a collagen membrane. Six weeks later, one titanium sandblasted and acid-etched (SLA) implant was inserted at the centre of each previously created defect. The animals were sacrificed after 6 weeks of healing.

Results: Implants placed in bone previously grafted with Bio-Oss, PerioGlas or Ostim-Paste obtained a larger extent of osseointegration, although not statistically significant, than implants placed in non-grafted bone. The three grafting materials seemed to perform in a similar way concerning their contribution towards implant osseointegration. All grafting materials appeared to be osteoconductive, thus leading to the formation of bridges of mineralized bone extending from the cortical plate towards the implants surface through the graft scaffold.

Conclusions: Grafting with the above-mentioned biomaterials did not add any advantage to the osseointegration of titanium SLA implants in a self-contained defect.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Regeneration / drug effects*
  • Bone Substitutes / pharmacology*
  • Ceramics / pharmacology
  • Dental Implantation, Endosseous / methods
  • Dental Implants, Single-Tooth*
  • Dental Stress Analysis
  • Durapatite / pharmacology
  • Male
  • Minerals / pharmacology
  • Osseointegration / drug effects*
  • Rabbits
  • Tibia


  • Bio-Oss
  • Bioglass
  • Bone Substitutes
  • Minerals
  • Durapatite