Aging: a sirtuin shake-up?

Cell. 2008 Nov 28;135(5):797-8. doi: 10.1016/j.cell.2008.11.008.


The yeast sirtuin (Sir2) is a histone deacetylase that modulates yeast replicative life span by suppressing genome instability through chromatin modification. In this issue, Oberdoerffer et al. (2008) report that SIRT1, the mammalian ortholog of Sir2, is involved in DNA damage-induced chromatin reorganization, which promotes genome stability in mammalian cells.

Publication types

  • Comment

MeSH terms

  • Aging / genetics*
  • Animals
  • DNA Repair
  • Genomic Instability
  • Sirtuins / genetics*
  • Yeasts


  • Sirtuins