Adenosine receptor agonists for promotion of dermal wound healing

Biochem Pharmacol. 2009 Apr 1;77(7):1117-24. doi: 10.1016/j.bcp.2008.11.002. Epub 2008 Nov 12.


Wound healing is a dynamic and complex process that involves a well-coordinated, highly regulated series of events including inflammation, tissue formation, revascularization and tissue remodeling. However, this orderly sequence is impaired in certain pathophysiological conditions such as diabetes mellitus, venous insufficiency, chronic glucocorticoid use, aging and malnutrition. Together with proper wound care, promotion of the healing process is the primary objective in the management of chronic poorly healing wounds. Recent studies have demonstrated that A(2A) adenosine receptor agonists promote wound healing in normal and diabetic animals and one such agonist, Sonedenoson, is currently being evaluated as a prospective new therapy of diabetic foot ulcers. We will review the mechanisms by which adenosine receptor activation affects the function of the cells and tissues that participate in wound healing, emphasizing the potential beneficial impact of adenosine receptor agonists in diabetic impaired healing.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / pharmacology
  • Adenosine / therapeutic use
  • Animals
  • Diabetic Foot / drug therapy
  • Diabetic Foot / metabolism
  • Humans
  • Neovascularization, Physiologic / drug effects
  • Neovascularization, Physiologic / physiology
  • Purinergic P1 Receptor Agonists*
  • Receptors, Purinergic P1 / metabolism
  • Skin Diseases / drug therapy*
  • Skin Diseases / metabolism
  • Wound Healing / drug effects
  • Wound Healing / physiology*


  • Purinergic P1 Receptor Agonists
  • Receptors, Purinergic P1
  • Adenosine