Successful pregnancy after rituximab in a women with recurrent in vitro fertilisation failures and anti-phospholipid antibody positive

Ir J Med Sci. 2009 Dec;178(4):531-3. doi: 10.1007/s11845-008-0265-5.


We report a case of successful pregnancy after rituximab in a patient with a history of in vitro fertilisation (IVF) failures and positive anti-cardiolipin antibody (ACA). Following a course of rituximab, her ACA became negative and she successfully conceived with IVF treatment. This is the first case in literature describing the use of rituximab therapy in this clinical scenario.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Anticardiolipin / drug effects
  • Antibodies, Anticardiolipin / metabolism*
  • Antibodies, Monoclonal, Murine-Derived / pharmacology
  • Antibodies, Monoclonal, Murine-Derived / therapeutic use*
  • Female
  • Humans
  • Immunologic Factors / pharmacology
  • Immunologic Factors / therapeutic use*
  • Infertility, Female / drug therapy*
  • Infertility, Female / immunology
  • Live Birth
  • Pregnancy
  • Rituximab


  • Antibodies, Anticardiolipin
  • Antibodies, Monoclonal, Murine-Derived
  • Immunologic Factors
  • Rituximab