Network integration and graph analysis in mammalian molecular systems biology

IET Syst Biol. 2008 Sep;2(5):206-21. doi: 10.1049/iet-syb:20070075.


Abstraction of intracellular biomolecular interactions into networks is useful for data integration and graph analysis. Network analysis tools facilitate predictions of novel functions for proteins, prediction of functional interactions and identification of intracellular modules. These efforts are linked with drug and phenotype data to accelerate drug-target and biomarker discovery. This review highlights the currently available varieties of mammalian biomolecular networks, and surveys methods and tools to construct, compare, integrate, visualise and analyse such networks.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Algorithms*
  • Animals
  • Computer Simulation
  • Databases, Protein*
  • Humans
  • Mammals
  • Models, Biological*
  • Protein Interaction Mapping / methods*
  • Proteome / chemistry*
  • Proteome / metabolism*
  • Signal Transduction / physiology*
  • Structure-Activity Relationship
  • Systems Biology / methods*
  • Systems Integration


  • Proteome