Raptor swoops in on metabolism

Cell Metab. 2008 Nov;8(5):343-4. doi: 10.1016/j.cmet.2008.10.007.

Abstract

The mammalian target of rapamycin (mTOR) serine/threonine kinase plays a central role in insulin signaling and cell growth, through two distinct complexes with its subunits raptor or rictor. In this issue, two reports utilizing tissue-specific knockout mice detail key roles for mTORC1 in skeletal muscle and adipose tissue function.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Adipose Tissue / metabolism*
  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology*
  • Insulin / physiology
  • Mechanistic Target of Rapamycin Complex 1
  • Mice
  • Multiprotein Complexes
  • Muscle, Skeletal / metabolism*
  • Muscle, Skeletal / pathology
  • Muscular Dystrophies / metabolism
  • Muscular Dystrophies / pathology
  • Proteins
  • Rapamycin-Insensitive Companion of mTOR Protein
  • Regulatory-Associated Protein of mTOR
  • Signal Transduction / physiology
  • TOR Serine-Threonine Kinases
  • Transcription Factors / metabolism*

Substances

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Insulin
  • Multiprotein Complexes
  • Proteins
  • Rapamycin-Insensitive Companion of mTOR Protein
  • Regulatory-Associated Protein of mTOR
  • Rptor protein, mouse
  • Transcription Factors
  • rictor protein, mouse
  • TOR Serine-Threonine Kinases
  • Mechanistic Target of Rapamycin Complex 1