Abstract
Imipenem plasma concentrations were analyzed in 57 febrile neutropenic patients using the NONMEM program. The recommended 2-g/day regimen achieved coverage of the most common bacteria (MIC(90) = 1 mg/liter) during the whole dosing interval in only 53% of patients. This goal was achieved in 90% of patients with 3 g/day.
MeSH terms
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Adolescent
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Adult
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Aged
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Anti-Bacterial Agents / administration & dosage*
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Anti-Bacterial Agents / pharmacokinetics
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Anti-Bacterial Agents / therapeutic use*
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Antineoplastic Agents / adverse effects
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Antineoplastic Agents / therapeutic use
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Female
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Glomerular Filtration Rate
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Guidelines as Topic
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Hematologic Neoplasms / complications*
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Hematologic Neoplasms / drug therapy
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Humans
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Imipenem / administration & dosage*
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Imipenem / pharmacokinetics
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Imipenem / therapeutic use*
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Male
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Middle Aged
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Models, Biological
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Neutropenia / chemically induced*
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Neutropenia / complications*
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Young Adult
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Imipenem