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Review
, 154 (Pt 12), 3609-3623

Structure and Function of the LysR-type Transcriptional Regulator (LTTR) Family Proteins

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Review

Structure and Function of the LysR-type Transcriptional Regulator (LTTR) Family Proteins

Sarah E Maddocks et al. Microbiology.

Abstract

The LysR family of transcriptional regulators represents the most abundant type of transcriptional regulator in the prokaryotic kingdom. Members of this family have a conserved structure with an N-terminal DNA-binding helix-turn-helix motif and a C-terminal co-inducer-binding domain. Despite considerable conservation both structurally and functionally, LysR-type transcriptional regulators (LTTRs) regulate a diverse set of genes, including those involved in virulence, metabolism, quorum sensing and motility. Numerous structural and transcriptional studies of members of the LTTR family are helping to unravel a compelling paradigm that has evolved from the original observations and conclusions that were made about this family of transcriptional regulators.

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