Evaluation of a synthetic wound dressing capable of releasing silver sulfadiazine

J Burn Care Rehabil. Mar-Apr 1991;12(2):106-15. doi: 10.1097/00004630-199103000-00004.


A silver sulfadiazine-impregnated poly-L-leucine wound dressing, AgSD-medicated wound dressing, was evaluated for antibacterial capacity against Pseudomonas aeruginosa and cytotoxicity to human fibroblasts and human epidermal keratinocytes. This wound dressing contained 0.4 mg AgSD/cm2. Antibacterial capacity was examined on experimentally infected wound surfaces (3.4 x 10(4) P. aeruginosa organisms/gm) on the dorsum of mice. The AgSD-medicated wound dressing showed effective bacterial control. Cytotoxicity was examined on a monolayer of cells formed in culture dishes. Cellular damage was reduced by the controlled release of AgSD from the hydrophobic poly-L-leucine sponge matrix of the AgSD-medicated wound dressing. Cytotoxicity of the AgSD-medicated wound dressing was much lower than that of 1% AgSD cream.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Bacterial Infections / prevention & control
  • Biocompatible Materials / therapeutic use
  • Burns / complications
  • Cell Count / drug effects
  • Cells, Cultured
  • Coated Materials, Biocompatible*
  • Delayed-Action Preparations
  • Fibroblasts / drug effects
  • Humans
  • Mice
  • Occlusive Dressings*
  • Pseudomonas aeruginosa / drug effects
  • Silver Sulfadiazine / toxicity*
  • Skin / cytology


  • Biobrane
  • Biocompatible Materials
  • Coated Materials, Biocompatible
  • Delayed-Action Preparations
  • Silver Sulfadiazine