Decreased intrathecal synthesis of prostaglandin D2 synthase in the cerebrospinal fluid of patients with acute inflammatory demyelinating polyneuropathy

J Neuroimmunol. 2009 Jan 3;206(1-2):100-5. doi: 10.1016/j.jneuroim.2008.10.011. Epub 2008 Dec 2.


Prostaglandin D(2) synthase (PGDS) is the most abundant brain protein in cerebrospinal fluid (CSF) and is tied closely with inflammatory processes. This study investigated whether CSF PGDS levels in patients with acute inflammatory demyelinating polyneuropathy (AIDP) are altered. The results suggest that PGDS concentration is significantly increased in the CSF of AIDP patients compared with the control patients (p<0.05) due to a blood-CSF barrier dysfunction, whereas the intrathecal synthesis of PGDS, reflected by the CSF PGDS/albumin ratio, is significantly decreased in AIDP compared with the control group (p<0.05). The changes of CSF PGDS/albumin ratio are only observed in AIDP patients, but not in Miller Fisher Syndrome (MFS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), or multiple sclerosis (MS) patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Albumins / cerebrospinal fluid
  • Blotting, Western
  • Female
  • Guillain-Barre Syndrome / cerebrospinal fluid*
  • Humans
  • Intramolecular Oxidoreductases / biosynthesis
  • Intramolecular Oxidoreductases / cerebrospinal fluid*
  • Intramolecular Oxidoreductases / genetics
  • Linear Models
  • Lipocalins / biosynthesis
  • Lipocalins / cerebrospinal fluid*
  • Lipocalins / genetics
  • Male
  • Middle Aged
  • Miller Fisher Syndrome / cerebrospinal fluid
  • Multiple Sclerosis / cerebrospinal fluid
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / cerebrospinal fluid


  • Albumins
  • Lipocalins
  • Intramolecular Oxidoreductases
  • prostaglandin R2 D-isomerase