Sleep apnea syndrome: implications on cardiovascular diseases

Crit Pathw Cardiol. 2008 Dec;7(4):248-53. doi: 10.1097/HPC.0b013e31818ae644.


Global risk assessment is the standard of care for coronary artery disease management. In this setting, sleep apnea syndrome, which includes obstructive sleep apnea and central sleep apnea, is being increasingly recognized as a potentially modifiable risk factor for coronary artery disease. Emerging evidence points toward a cause and effect relationship between sleep apnea syndrome and medical conditions like insulin resistance, hypertension, heart failure, and myocardial ischemia. The effects of sleep apnea on coronary artery disease can be independent of many traditional risk factors. Continuous positive airway pressure has been shown to decrease inflammatory markers that are elevated in sleep apnea syndrome. Well-designed randomized controlled clinical trials are needed to better establish the role of sleep apnea in the genesis and progression of coronary artery disease.

Publication types

  • Review

MeSH terms

  • Aged
  • Aged, 80 and over
  • Comorbidity
  • Disease Progression
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Polysomnography
  • Positive-Pressure Respiration
  • Prognosis
  • Risk Assessment
  • Severity of Illness Index
  • Sleep Apnea Syndromes / diagnosis*
  • Sleep Apnea Syndromes / epidemiology*
  • Sleep Apnea Syndromes / therapy
  • Sleep Apnea, Central / diagnosis
  • Sleep Apnea, Central / epidemiology
  • Sleep Apnea, Central / therapy
  • Sleep Apnea, Obstructive / diagnosis
  • Sleep Apnea, Obstructive / epidemiology*
  • Sleep Apnea, Obstructive / therapy
  • Survival Rate