Immunohistochemical expression of MMP-2, MMP-9 and COX-2 in Stage IA malignant polyps of the endometrium

Eur J Gynaecol Oncol. 2008;29(5):444-9.


Objective: To study whether endometrioid type malignant endometrial polyps (MEP) are different from endometrium cancer not associated with polyps (ECNAP) in means of immunohistochemical expressions of MMP-2, MMP-9 and COX-2.

Methods: Archived tissue samples of eight MEP, eight ECNAP and 16 benign endometrial polyps were selected and immunohistochemically analyzed for MMP-2, MMP-9 and COX-2 expression.

Results: MMP-2 and MMP-9 were overexpressed in ECNAP compared to MEP and benign endometrial polyps (p < 0.05). MMP-2 and MMP-9 expressions were not different in the malignant part of MEP, benign part of MEP and benign endometrial polyps. COX-2 expression was found to be higher in benign lesions, although this was not statistically significant.

Conclusion: Similar immunohistochemical expression of MMP-2, MMP-9 and COX-2 within a polyp and with benign polyps may indicate an immunohistochemically indolent characteristic of MEP.

MeSH terms

  • Cyclooxygenase 2 / analysis*
  • Endometrial Neoplasms / chemistry*
  • Female
  • Humans
  • Immunohistochemistry
  • Matrix Metalloproteinase 2 / analysis*
  • Matrix Metalloproteinase 9 / analysis*
  • Polyps / chemistry*


  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 9