Donovanosis with auto-amputation of penis in a HIV-2 infected person

Indian J Dermatol Venereol Leprol. 2008 Sep-Oct;74(5):490-2. doi: 10.4103/0378-6323.44308.


Donovanosis is a slowly progressive, granulomatous ulcerative disease , caused by Klebsiella (Calymmatobacterium) granulomatis. The disease is known to persist for years together, leading to complications. A male patient aged 30 years with underlying HIV-2 infection presented to the department of STD with painful ulceration over the genital region of 5 months duration, with absence of penis. Tissue smear from the ulcer and histopathological examination revealed large histiocytes with intracellular Donovan bodies (Pund cell). A final diagnosis of donovanosis with auto-amputation of penis with HIV-2 infection was made. The old conventional medicines, viz. streptomycin, doxycycline and amoxycillin, were effective. Though HIV-2 infections are milder than HIV-1 infections in all aspects, donovanosis in this HIV-2 infected case presented with complications. However, since the CD4 count was 748 cells/cmm, the severity is attributed to the long standing nature and negligence by the patient, and not to possible immunodeficiency.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amputation, Traumatic / complications
  • Amputation, Traumatic / diagnosis*
  • Granuloma Inguinale / complications
  • Granuloma Inguinale / diagnosis*
  • HIV Infections / complications
  • HIV Infections / diagnosis*
  • HIV-2*
  • Humans
  • Male
  • Penis / injuries*
  • Penis / virology