Influence of bioengineered skin substitutes on diabetic foot ulcer and venous leg ulcer outcomes

J Wound Care. 2008 Dec;17(12):517-27. doi: 10.12968/jowc.2008.17.12.31766.

Abstract

This systematic review indicates that bioengineered skin substitutes with a dermal component may improve healing outcomes in diabetic foot ulcers and venous leg ulcers. However, better designed trials with longer follow-up periods are needed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Cell Culture Techniques
  • Chronic Disease
  • Coated Materials, Biocompatible / therapeutic use
  • Collagen / therapeutic use
  • Diabetic Foot / therapy*
  • Health Services Needs and Demand
  • Humans
  • Randomized Controlled Trials as Topic
  • Research Design
  • Safety
  • Skin Transplantation
  • Skin, Artificial* / standards
  • Skin, Artificial* / supply & distribution
  • Treatment Outcome
  • Varicose Ulcer / therapy*
  • Wound Healing

Substances

  • Apligraf
  • Biobrane
  • Coated Materials, Biocompatible
  • TransCyte
  • Collagen