Treatment of tuberculosis in children

Expert Rev Anti Infect Ther. 2008 Dec;6(6):939-57. doi: 10.1586/14787210.6.6.939.


The treatment of children with TB is influenced by a number of factors specific to both the bacterium and the child. We review the variables impacting the selection of individual medications; indications, pharmacology, dosing and side effects for first- and second-line agents; adjunctive therapy; and special cases, including treatment of TB in HIV-infected children and multidrug-resistant TB. Finally, evolving trends in TB therapy, such as the impact of HIV and multidrug-resistant TB on future therapeutics, emerging or re-emerging medication options, shorter-course regimens and immunomodulation, are discussed.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Antitubercular Agents / administration & dosage
  • Antitubercular Agents / adverse effects
  • Antitubercular Agents / therapeutic use*
  • Breast Feeding
  • Chemotherapy, Adjuvant
  • Child
  • Child, Preschool
  • Combined Modality Therapy
  • Drug Resistance, Multiple, Bacterial
  • Female
  • HIV Infections / complications
  • Humans
  • Infant
  • Infant, Newborn
  • Pregnancy
  • Risk Factors
  • Tuberculosis / complications
  • Tuberculosis / drug therapy*


  • Antitubercular Agents