Dynamic contrast-enhanced T2*-weighted MR imaging: a peritumoral brain oedema study

J Neuroradiol. 2009 May;36(2):88-92. doi: 10.1016/j.neurad.2008.10.001. Epub 2008 Dec 2.


Background and purpose: Glioma and meningioma are the two most common types of primary brain tumor. The aim of the present study was to analyze, using dynamic susceptibility contrast MR perfusion imaging, the effect of angiogenesis on peritumoral tissue.

Methods: In this prospective study, conducted from December 2003 to March 2005, out of 18 patients recruited, 12 were included (six with meningioma, six with glioblastoma). Using rates of maximum signal drop (MSD), we drew regions of interest (ROI) starting near the lesion, and gradually moving outwards to areas of distant edema in axial and sagittal planes at 10, 20 and 30 mm from the tumor. We also drew ROI on the contralateral brain white matter to obtain a normal baseline for comparison (relative MSD; rMSD).

Results: In regions of peritumoral T2 hypersignals, we observed a decrease in rMSD with distance from glioblastoma due to reduced angiogenesis, and an increase in rMSD with distance from meningioma, probably due to a reduced mass effect.

Conclusion: In our study, dynamic susceptibility contrast MR perfusion imaging, using MSD as a parameter, revealed differences between meningioma and glioblastoma peritumoral tissue due to changes in angiogenesis.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Brain / pathology*
  • Brain Edema / etiology
  • Brain Edema / pathology*
  • Brain Mapping / methods
  • Brain Neoplasms / complications
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / pathology*
  • Diagnostic Imaging
  • Female
  • Glioma / complications
  • Glioma / diagnosis
  • Glioma / pathology*
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods*
  • Male
  • Meningeal Neoplasms / complications
  • Meningeal Neoplasms / diagnosis
  • Meningeal Neoplasms / pathology*
  • Meningioma / complications
  • Meningioma / diagnosis
  • Meningioma / pathology*
  • Middle Aged
  • Prospective Studies
  • Signal Processing, Computer-Assisted