Abstract
Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcinosis
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Calcium Compounds / analysis
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Durapatite / analysis
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Female
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry*
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Mammary Neoplasms, Experimental / chemistry
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Mammary Neoplasms, Experimental / diagnostic imaging*
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Mammary Neoplasms, Experimental / metabolism*
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Organotechnetium Compounds / chemical synthesis
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Organotechnetium Compounds / chemistry*
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Rats
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Spectroscopy, Near-Infrared / methods*
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Tomography, Emission-Computed, Single-Photon / methods*
Substances
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Calcium Compounds
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Fluorescent Dyes
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Organotechnetium Compounds
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Durapatite