MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders

Int J Immunogenet. 2009 Feb;36(1):69-72. doi: 10.1111/j.1744-313X.2008.00816.x. Epub 2008 Nov 25.


Several lines of evidence suggest that chemokines play an important role in asthma and allergy. We analysed polymorphisms at -2518A/G and -2076A/T of MCP-1 and V64I of CCR2 gene in healthy subjects (n = 306) and allergic patients (n = 332). Allele and genotype frequencies did not differ significantly between groups. Nevertheless, MCP-1 variants were associated with allergen sensitization. The results suggest that MCP-1, but not CCR2 gene variants, may participate in the pathogenesis of allergic phenotypes at least in the Caucasian population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Case-Control Studies
  • Chemokine CCL2 / genetics*
  • Czech Republic / epidemiology
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Hypersensitivity / epidemiology
  • Hypersensitivity / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Receptors, CCR2 / genetics*


  • CCL2 protein, human
  • CCR2 protein, human
  • Chemokine CCL2
  • Receptors, CCR2