Regulation of Cadherin Trafficking

Traffic. 2009 Mar;10(3):259-67. doi: 10.1111/j.1600-0854.2008.00862.x. Epub 2008 Dec 4.

Abstract

Cadherins are a large family of cell-cell adhesion molecules that tether cytoskeletal networks of actin and intermediate filaments to the plasma membrane. This function of cadherins promotes tissue organization and integrity, as demonstrated by numerous disease states that are characterized by the loss of cadherin-based adhesion. However, plasticity in cell adhesion is often required in cellular processes such as tissue patterning during development and epithelial migration during wound healing. Recent work has revealed a pivotal role for various membrane trafficking pathways in regulating cellular transitions between quiescent adhesive states and more dynamic phenotypes. The regulation of cadherins by membrane trafficking is emerging as a key player in this balancing act, and studies are beginning to reveal how this process goes awry in the context of disease. This review summarizes the current understanding of how cadherins are routed and how the interface between cadherins and membrane trafficking pathways regulates cell surface adhesive potential. Particular emphasis is placed on the regulation of cadherin trafficking by catenins and the interplay between growth factor signaling pathways and cadherin endocytosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cadherins / chemistry
  • Cadherins / metabolism*
  • Catenins / metabolism
  • Disease
  • Endocytosis
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Protein Transport

Substances

  • Cadherins
  • Catenins
  • Intercellular Signaling Peptides and Proteins