Nontypeable Haemophilus Influenzae as a Pathogen in Children

Pediatr Infect Dis J. 2009 Jan;28(1):43-8. doi: 10.1097/INF.0b013e318184dba2.

Abstract

Nontypeable Haemophilus influenzae is a significant pathogen in children, causing otitis media, sinusitis, conjunctivitis, pneumonia, and occasionally invasive infections. H. influenzae type b conjugate vaccines have no effect on infections caused by nontypeable strains because nontypeable strains are nonencapsulated. Approximately, one-third of episodes of otitis media are caused by nontypeable H. influenzae and the bacterium is the most common cause of recurrent otitis media. Recent progress in elucidating molecular mechanisms of pathogenesis, understanding the role of biofilms in otitis media and an increasing understanding of immune responses have potential for development of novel strategies to improve prevention and treatment of otitis media caused by nontypeable H. influenzae. Feasibility of vaccination for prevention of otitis media due to nontypeable H. influenzae was recently demonstrated in a clinical trial with a vaccine that included the surface virulence factor, protein D.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carrier State / microbiology
  • Cystic Fibrosis / microbiology
  • Haemophilus Infections / immunology
  • Haemophilus Infections / microbiology*
  • Haemophilus Infections / pathology
  • Haemophilus Infections / prevention & control
  • Haemophilus Vaccines / immunology
  • Haemophilus Vaccines / therapeutic use
  • Haemophilus influenzae / classification
  • Haemophilus influenzae / isolation & purification
  • Haemophilus influenzae / pathogenicity*
  • Humans
  • Nasopharynx / microbiology
  • Otitis Media / microbiology

Substances

  • Haemophilus Vaccines