Meconium aspiration syndrome: historical aspects

J Perinatol. 2008 Dec:28 Suppl 3:S3-7. doi: 10.1038/jp.2008.162.


The meconium aspiration syndrome (MAS) is a common problem that continues to concern perinatologists and neonatologists. MAS is defined as respiratory distress in an infant born through meconium-stained amniotic fluid (MSAF) whose symptoms cannot be otherwise explained. This disorder may be life threatening, complicated by respiratory failure, pulmonary air leaks and persistent pulmonary hypertension. Approaches to the prevention of MAS have changed over time with collaboration between obstetricians and pediatricians forming the foundations for care. This report details the management of babies delivered with associated MSAF before the accumulation of evidence for best practice through appropriately powered, prospective randomized controlled trials.

Publication types

  • Review

MeSH terms

  • Amniotic Fluid / physiology
  • Evidence-Based Medicine
  • Extracorporeal Membrane Oxygenation
  • Glucocorticoids / therapeutic use*
  • Humans
  • Hypertension, Pulmonary / etiology*
  • Infant, Newborn
  • Meconium / physiology
  • Meconium Aspiration Syndrome / complications
  • Meconium Aspiration Syndrome / drug therapy
  • Meconium Aspiration Syndrome / prevention & control*
  • Meconium Aspiration Syndrome / therapy*


  • Glucocorticoids