Association between lumbar bone mineral density and vascular stiffness as assessed by pulse wave velocity in postmenopausal women

J Bone Miner Metab. 2009;27(1):89-94. doi: 10.1007/s00774-008-0014-x. Epub 2008 Dec 5.


Recent studies have showed a significant correlation between vascular calcification and bone mineral density (BMD). Therefore, an investigation was carried out on the association between arterial stiffness, lumbar BMD and bone metabolic markers in Japanese postmenopausal women. Brachial-ankle PWV (baPWV) and BMD of the lumbar spine and serum bone-specific alkaline phosphatase (BAP) levels in 143 postmenopausal women were measured, where there was a significant negative correlation between baPWV and BMD (r = -0.21; P = 0.0135). An additional analysis included the remaining 75 subjects, but excluded subjects with hypertension and obesity. Here, a more negative correlation between baPWV and BMD (r = -0.315; P = 0.006), and a positive correlation between baPWV and BAP (r = 0.248; P = 0.032) were also significant. A group analysis, where the women were age matched and stratified into three groups of different bone density, i.e., normal BMD, osteopenic and osteoporotic, were further made. This showed lower PWV values in the normal BMD group than in the other two groups. A study also showed that the tertile with the highest BAP was associated with significantly higher PWV values than the other tertiles. However, when the multiple linear regression analysis was carried out, there was no correlation between PWV and BAP values. Low BMD and arterial stiffness show some correlation, suggesting that BAP may reflect the degree of arterial stiffness present.

MeSH terms

  • Aged
  • Atherosclerosis / pathology
  • Atherosclerosis / physiopathology
  • Blood Flow Velocity*
  • Bone Density*
  • Compliance
  • Female
  • Humans
  • Lumbar Vertebrae / anatomy & histology*
  • Middle Aged
  • Postmenopause*
  • Pulsatile Flow*
  • Statistics as Topic
  • Vascular Resistance*