Role of bone in osteoarthritis pathogenesis

Med Clin North Am. 2009 Jan;93(1):25-35, xv. doi: 10.1016/j.mcna.2008.09.006.


Much of the attention in developing diagnostic tools and therapeutic interventions for the management of osteoarthritis (OA) has focused on the preservation or repair of articular cartilage. It is clear that all of the joint components, including the ligaments, tendons, capsule, synovial lining, and periarticular bone, undergo structural and functional alterations during the course of OA progression. This article focuses on the specific skeletal features of OA and the putative mechanisms involved in their pathogenesis.

MeSH terms

  • Bone Remodeling / physiology
  • Bone and Bones / pathology*
  • Bone and Bones / physiopathology*
  • Cartilage, Articular / physiopathology
  • Humans
  • Joints / pathology
  • Joints / physiopathology
  • Osteoarthritis / pathology*
  • Osteoarthritis / physiopathology*
  • Osteophyte / physiopathology