The symptoms of osteoarthritis and the genesis of pain

Med Clin North Am. 2009 Jan;93(1):83-100, xi. doi: 10.1016/j.mcna.2008.08.008.


This article delineates the characteristic symptoms and signs associated with OA and how they can be used to make the clinical diagnosis. The predominant symptom in most patients is pain. The remainder of the article focuses on what we know causes pain in OA and contributes to its severity. Much has been learned over recent years; however, for the budding researcher much of this puzzle remains unexplored or inadequately understood.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Female
  • Humans
  • Joints / innervation
  • Male
  • Nociceptors
  • Osteoarthritis / diagnosis
  • Osteoarthritis / physiopathology*
  • Pain / etiology*
  • Pain Measurement