Breaking the VE-cadherin bonds

FEBS Lett. 2009 Jan 5;583(1):1-6. doi: 10.1016/j.febslet.2008.11.032. Epub 2008 Dec 4.


Exchanges between the blood compartment and the surrounding tissues require a tight regulation by the endothelial barrier. Recent reports inferred that VE-cadherin, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. Indeed, a growing number of permeability inducing factors (PIFs) was shown to elicit signaling mechanisms culminating in VE-cadherin destabilization and global alteration of the junctional architecture. Conversely, anti-PIFs protect from VE-cadherin disruption and enhance cell cohesion. These findings provide evidence on how endothelial cell-cell junctions impact the vascular network, and change our perception about normal and aberrant angiogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigens, CD / metabolism*
  • Cadherins / metabolism*
  • Cell Adhesion
  • Cell Membrane Permeability
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / metabolism
  • Endothelium, Vascular / physiology*
  • Humans
  • Intercellular Junctions / metabolism
  • Intercellular Junctions / physiology*


  • Antigens, CD
  • Cadherins
  • cadherin 5