Cancer and complement

Nat Biotechnol. 2008 Dec;26(12):1348-9. doi: 10.1038/nbt1208-1348.

Abstract

A component of the complement system promotes tumor growth by activating myeloid-derived suppressor cells.

MeSH terms

  • Animals
  • Complement C5a / antagonists & inhibitors
  • Complement C5a / immunology
  • Complement System Proteins / immunology*
  • Humans
  • Immunosuppression*
  • Inflammation
  • Inflammation Mediators / immunology
  • Mice
  • Myeloid Cells / immunology*
  • Myeloid Cells / physiology
  • Neoplasms / immunology*

Substances

  • Inflammation Mediators
  • Complement C5a
  • Complement System Proteins