Acanthosis nigricans: a practical approach to evaluation and management

Dermatol Online J. 2008 Sep 15;14(9):2.

Abstract

Acanthosis nigricans is a dermatosis characterized by thickened, hyperpigmented plaques, typically of the intertriginous surfaces and neck. Common in some populations, its prevalence depends on race. Clinicians should recognize acanthosis nigricans; it heralds disorders ranging from endocrinologic disturbances to malignancy. In this review, we discuss the pathogenesis of acanthosis nigricans and its clinical implications and management.

Publication types

  • Review

MeSH terms

  • Acanthosis Nigricans* / diagnosis
  • Acanthosis Nigricans* / drug therapy
  • Acanthosis Nigricans* / epidemiology
  • Acanthosis Nigricans* / etiology
  • Acanthosis Nigricans* / pathology
  • Acanthosis Nigricans* / radiotherapy
  • Adolescent
  • Calcitriol / analogs & derivatives
  • Calcitriol / pharmacology
  • Child
  • Disease Susceptibility
  • Ethnic Groups / genetics
  • Female
  • Fish Oils / therapeutic use
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Insulin Resistance
  • Insulin-Like Growth Factor I / physiology
  • Low-Level Light Therapy
  • Male
  • Neoplasms / complications
  • Prevalence
  • Receptor Protein-Tyrosine Kinases / physiology
  • Retinoids / therapeutic use

Substances

  • Fish Oils
  • Hypoglycemic Agents
  • Retinoids
  • calcipotriene
  • Insulin-Like Growth Factor I
  • Receptor Protein-Tyrosine Kinases
  • Calcitriol