Malignant transformation of donovanosis (granuloma inguinale) in a HIV-positive patient

Dermatol Online J. 2008 Sep 15;14(9):8.

Abstract

Donovanosis is endemic in various parts of the world. Although donovanosis has been reported to co-exist with the human immunodeficiency virus (HIV) infection, to our knowledge there have been no reports of co-existent squamous cell carcinoma (SCC) in an HIV positive patient. In our case the patient did not respond to treatment for donovanosis and on biopsy we realized that the patient had coexistent SCC, which is hitherto unreported with granuloma inguinale.

Publication types

  • Case Reports

MeSH terms

  • Amputation, Surgical
  • Anti-Bacterial Agents / therapeutic use
  • Anti-HIV Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active
  • Carcinoma, Squamous Cell / complications*
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / therapy
  • Cell Transformation, Neoplastic
  • Chemotherapy, Adjuvant
  • Combined Modality Therapy
  • Disease Progression
  • Doxycycline / therapeutic use
  • Granuloma Inguinale / complications*
  • Granuloma Inguinale / drug therapy
  • Granuloma Inguinale / pathology
  • HIV Infections / complications*
  • HIV Infections / diagnosis
  • HIV Infections / drug therapy
  • Humans
  • Male
  • Penile Neoplasms / complications*
  • Penile Neoplasms / pathology
  • Penile Neoplasms / therapy
  • Radiotherapy, Adjuvant
  • Skin Neoplasms / complications*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / therapy
  • Skin Ulcer / etiology
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Anti-HIV Agents
  • Doxycycline