Ratcheting Myc

Cancer Cell. 2008 Dec 9;14(6):425-6. doi: 10.1016/j.ccr.2008.11.008.


In this issue of Cancer Cell, Murphy et al. describe a mouse model designed to examine the biological effects of different levels of deregulated c-myc expression. They provide evidence that distinct threshold levels of Myc are required for increased proliferation and for apoptosis in different tissues.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis
  • Cell Proliferation
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Mice
  • Models, Biological
  • Neoplasms / metabolism*
  • Neoplasms / therapy
  • Proto-Oncogene Proteins c-myc / metabolism
  • Proto-Oncogene Proteins c-myc / physiology*
  • Transcription Factors / metabolism


  • Proto-Oncogene Proteins c-myc
  • Transcription Factors