AKT and oxidative stress team up to kill cancer cells

Cancer Cell. 2008 Dec 9;14(6):427-9. doi: 10.1016/j.ccr.2008.11.006.

Abstract

AKT, a protein kinase frequently hyperactivated in cancer, plays an important role in cell survival and contributes to tumor cell resistance to cytotoxic therapies. A new study in this issue of Cancer Cell shows that AKT also induces the accumulation of oxygen radicals, which can be exploited to selectively kill cancer cells containing high levels of AKT activity.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis
  • Cell Survival
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Models, Biological
  • Neoplasms / metabolism*
  • Oxidative Stress*
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Signal Transduction

Substances

  • Proto-Oncogene Proteins c-akt