The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary

Chem Biol Interact. 2009 Mar 16;178(1-3):99-109. doi: 10.1016/j.cbi.2008.10.058. Epub 2008 Nov 17.

Abstract

The short-chain dehydrogenase/reductase (SDR) superfamily represents one of the largest protein superfamilies known to date. Enzymes of this family usually catalyse NAD(P)(H) dependent reactions with a substrate spectrum ranging from polyols, retinoids, steroids and fatty acid derivatives to xenobiotics. We have currently identified 73 SDR superfamily members within the human genome. A status report of the human SDR superfamily is provided in terms of 3D structure determination, co-factor preferences, subcellular localisation and functional annotation. A simple scoring system for measuring structural and functional information (SFS score) has also been introduced to monitor the status of 5 key metrics. Currently there are 17 SDR members with an SFS score of zero indicating that almost a quarter of the human SDR superfamily lacks substantial functional annotation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computational Biology*
  • Models, Molecular
  • Oxidoreductases Acting on CH-CH Group Donors* / chemistry
  • Oxidoreductases Acting on CH-CH Group Donors* / genetics
  • Oxidoreductases Acting on CH-CH Group Donors* / metabolism
  • Protein Conformation
  • Structure-Activity Relationship

Substances

  • Oxidoreductases Acting on CH-CH Group Donors