Influence of an intravenous dose of aurothiomalate on the status of low-molecular-mass endogenous metabolites in blood plasma: a proton nuclear magnetic resonance (NMR) study

Agents Actions Suppl. 1991:32:65-9. doi: 10.1007/978-3-0348-7405-2_8.


The effect of aurothiomalate on the status of a wide range of low-molecular-mass endogenous metabolites in blood plasma obtained from animals treated with an intravenous dose of this second-line agent (150 mg/kg) has been assessed by high field proton Hahn spin-echo NMR spectroscopy. As well as modulating the effective concentrations of NMR-detectable biomolecules, aurothiomalate induces a time-dependent decrease in plasma levels of triacylglycerols with a corresponding elevation in the concentration of the ketone body 3-D-hydroxybutyrate, indicating an increased utilisation of fats for energy in rats treated with this 1:1 gold(I)-thiolate complex. These observations may reflect the toxic side-effects that are associated with aurothiomalate treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3-Hydroxybutyric Acid
  • Animals
  • Gold Sodium Thiomalate / administration & dosage
  • Gold Sodium Thiomalate / pharmacology*
  • Hydroxybutyrates / blood
  • Injections, Intravenous
  • Magnetic Resonance Spectroscopy
  • Male
  • Rats
  • Rats, Inbred Strains
  • Triglycerides / blood


  • Hydroxybutyrates
  • Triglycerides
  • Gold Sodium Thiomalate
  • 3-Hydroxybutyric Acid