Host interception of bacterial communication signals

Cell Host Microbe. 2008 Dec 11;4(6):507-9. doi: 10.1016/j.chom.2008.11.003.


Pathogenic Staphylococcus aureus employs a cell-to-cell communication system to control virulence factor expression in the host during infection. In this issue, Peterson et al. (2008) report that host lipoproteins can sequester the S. aureus communication signal and antagonize virulence factor expression and pathogenesis in a murine model of infection.

Publication types

  • Comment

MeSH terms

  • Animals
  • Bacterial Proteins / antagonists & inhibitors*
  • Lipoproteins / immunology*
  • Mice
  • Peptides, Cyclic
  • Staphylococcal Infections / immunology*
  • Staphylococcus aureus / pathogenicity*


  • AgrD protein, Staphylococcus
  • Bacterial Proteins
  • Lipoproteins
  • Peptides, Cyclic