Whole genome approaches in ischemic stroke

Stroke. 2009 Mar;40(3 Suppl):S61-3. doi: 10.1161/STROKEAHA.108.533182. Epub 2008 Dec 8.


Background and purpose: The field of ischemic stroke genetics is moving beyond candidate gene studies into the realm of genomewide association studies. Such studies have resulted in discoveries in diverse, complex disorders.

Methods: The author conducted an informal qualitative review of peer-reviewed medical literature.

Results: The power of genomewide association studies to confirm prior associations and establish new ones is illustrated by recent work focusing on type 2 diabetes mellitus. A pilot genomewide association study of ischemic stroke failed to identify a single gene of major effect.

Conclusions: Follow-up studies with substantially greater statistical power are essential and are being planned by the Wellcome Trust and others.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Brain Ischemia / genetics
  • Diabetes Mellitus, Type 2 / genetics
  • Female
  • Genome-Wide Association Study*
  • Humans
  • Male
  • Polymorphism, Single Nucleotide / genetics
  • Stroke / genetics*