Nocturnal nasal ventilation for treatment of patients with hypercapnic respiratory failure

Mayo Clin Proc. 1991 Jul;66(7):695-703. doi: 10.1016/s0025-6196(12)62081-3.


We reviewed the Mayo Clinic experience with nocturnal nasal ventilation (NNV) and retrospectively assessed the clinical benefits, patient compliance, and complications. NNV had been instituted in 26 patients with daytime hypercapnia and nocturnal hypoventilation due to neuromuscular diseases or chronic obstructive pulmonary disease. After initiation of NNV, 21 of 26 patients continued to use this treatment regularly (81% compliance rate) and considered their life-style improved. In this subset of patients, the arterial partial pressure of carbon dioxide during unassisted breathing decreased from 64 +/- 13 to 51 +/- 7 mm Hg, and the arterial partial pressure of oxygen increased from 58 +/- 12 to 68 +/- 8 mm Hg. No significant change was noted in the forced vital capacity or maximal respiratory pressures. Four of the five patients in whom NNV had been discontinued cited discomfort related to the mask or severity and poor prognosis of the underlying illness as reasons for cessation of treatment. We conclude that NNV is well tolerated by most patients and may improve alveolar ventilation and arterial oxygenation in patients with chronic respiratory failure.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Carbon Dioxide / blood
  • Chronic Disease
  • Female
  • Humans
  • Hypercapnia / complications
  • Hypercapnia / physiopathology
  • Hypercapnia / therapy*
  • Lung Diseases, Obstructive / therapy
  • Male
  • Middle Aged
  • Nose
  • Oxygen / blood
  • Patient Compliance
  • Positive-Pressure Respiration* / adverse effects
  • Positive-Pressure Respiration* / methods
  • Pulmonary Gas Exchange
  • Respiratory Insufficiency / complications
  • Respiratory Insufficiency / physiopathology
  • Respiratory Insufficiency / therapy*
  • Respiratory Muscles / physiopathology
  • Retrospective Studies


  • Carbon Dioxide
  • Oxygen