Long-term behavioral characterization of a rat model of intracerebral hemorrhage

Acta Neurochir Suppl. 2008:105:125-6. doi: 10.1007/978-3-211-09469-3_25.

Abstract

We tested the behavioral effects of intracerebral hemorrhage (ICH) in adult male rats. ICH was induced by collagenase injection into the basal ganglia and the rats were subjected to a longitudinal behavioral test battery. Both learning and memory deficits were detected shortly after injury. Two months after injury, there were still significant short- and long-term memory deficits. Rotarod testing also revealed long-term sensorimotor coordination deficits. No differences in activity levels were detected at any time. Thus, spontaneous ICH produced detectable cognitive and motor deficits that evolved over the course of 2 months. Along with histological analysis of infarct volume, this characterization provides a suitable baseline for the analysis of therapeutic interventions.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Behavior, Animal / physiology*
  • Cerebral Hemorrhage / chemically induced
  • Cerebral Hemorrhage / physiopathology*
  • Collagenases / pharmacology
  • Disease Models, Animal*
  • Male
  • Maze Learning / drug effects
  • Maze Learning / physiology
  • Motor Activity / drug effects
  • Motor Activity / physiology
  • Psychomotor Performance / drug effects
  • Psychomotor Performance / physiology
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Collagenases