Effect of interferon-gamma on B lymphocytes of patients with systemic lupus erythematosus

J Rheumatol. 1991 Mar;18(3):368-72.

Abstract

We studied the effect of interferon-gamma (IFN-gamma) on B cells in systemic lupus erythematosus (SLE). Low density B cells, which were fractionated on density gradients of Percoll, increased, and high density B cells decreased in number in SLE. Proliferative response of the high density B cells to interleukin 4 was reduced by IFN-gamma in normal controls, but not in SLE. IgG production of whole B cells induced by interleukin 2 or phytohemagglutinin induced T cell factors was enhanced by IFN-gamma in both normal controls and SLE in which activated B cells were thought to be increased in number. Therefore, IFN-gamma may be one of the factors which promote polyclonal B cell activation in SLE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • B-Lymphocytes / physiology*
  • Cell Division
  • Cell Fractionation
  • Humans
  • Immunoglobulin G / metabolism
  • Interferon-gamma / pharmacology*
  • Interleukin-2 / pharmacology
  • Interleukin-4 / pharmacology
  • Lupus Erythematosus, Systemic / immunology
  • Lupus Erythematosus, Systemic / pathology*
  • Lymphocyte Activation
  • Phytohemagglutinins / pharmacology
  • Prednisolone / pharmacology

Substances

  • Immunoglobulin G
  • Interleukin-2
  • Phytohemagglutinins
  • Interleukin-4
  • Interferon-gamma
  • Prednisolone