HMGA2, microRNAs, and stem cell aging

Cell. 2008 Dec 12;135(6):1013-6. doi: 10.1016/j.cell.2008.11.026.


Mammalian aging results from a replicative decline in the function of somatic stem cells and other self-renewing cells. Recent studies (Monzen et al., 2008; Nishino et al., 2008; Sanna et al., 2008; Weedon et al., 2008) link a chromatin-associated protein, HMGA2, to development, height, and mouse stem cell aging during late fetal development and young adulthood.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Cellular Senescence*
  • HMGA2 Protein / metabolism*
  • Mice / physiology*
  • MicroRNAs / metabolism*
  • Stem Cells / cytology*


  • HMGA2 Protein
  • MicroRNAs