Targeted Paclitaxel by conjugation to iron oxide and gold nanoparticles

J Am Chem Soc. 2009 Jan 14;131(1):66-8. doi: 10.1021/ja804947u.

Abstract

The Fe(3)O(4) nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Drug Delivery Systems / methods
  • Drug Screening Assays, Antitumor
  • Endothelial Cells / drug effects
  • Ferric Compounds / chemistry*
  • Gold / chemistry*
  • Humans
  • Maleimides / chemistry
  • Metal Nanoparticles / chemistry*
  • Paclitaxel / chemistry*
  • Paclitaxel / pharmacology
  • Polyethylene Glycols / chemistry
  • Succinimides / chemistry

Substances

  • Antineoplastic Agents, Phytogenic
  • Ferric Compounds
  • Maleimides
  • Succinimides
  • ferric oxide
  • Polyethylene Glycols
  • Gold
  • Paclitaxel