Morphological transformation of microglia in vitro

Brain Res. 1991 Apr 5;545(1-2):301-6. doi: 10.1016/0006-8993(91)91302-h.

Abstract

Isolated microglia underwent in vitro morphological transformation to ameboid, rod-shaped and ramified forms in response to several cytokines, factors from astrocytes, or factors which affect macrophage function. These morphological transformations were reversible. Examination of the enzymatic activity, superoxide anion formation and proliferative activity of these transformed microglia indicated that the ameboid forms were activated, rod-shaped microglia were proliferating, and the ramified forms were resting microglia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Astrocytes / physiology
  • Cell Differentiation / drug effects
  • Cell Division / drug effects
  • Cells, Cultured
  • Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology
  • Interferon-gamma / pharmacology
  • Interleukins / pharmacology
  • Lipopolysaccharides / pharmacology
  • Macrophages / cytology*
  • Macrophages / drug effects
  • Mesoderm / cytology*
  • Mice
  • Mice, Inbred C3H
  • Neuroglia / cytology*
  • Tetradecanoylphorbol Acetate / pharmacology

Substances

  • Interleukins
  • Lipopolysaccharides
  • Interferon-gamma
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Tetradecanoylphorbol Acetate