Moist Exposed Burn Ointment (MEBO) in partial thickness burns - a randomized, comparative open mono-center study on the efficacy of dermaheal (MEBO) ointment on thermal 2nd degree burns compared to conventional therapy

Eur J Med Res. 2008 Nov 24;13(11):505-10.


Objective: Wound healing in burn wounds presents a challenge in healthcare, and there is still a lack of alternatives in topical burn wound treatments. - The purpose of this study was to evaluate the efficacy of a new therapeutic ointment (MEBO) in the treatment of partial thickness burns.

Methods: 40 patients received either topical treatment with Moist Exposed Burn Ointment (MEBO) or standard Flammazine treatment. All patients suffered from partial-thickness burn injuries (< 20% TBSA). Wounds were evaluated for 60 up to days regarding wound healing, water loss, inflammation, and pain alleviation.

Results: For transepidermal water loss, there was a difference of 2.3 gr/m2/h between MEBO, and Flammazine, favoring MEBO. However, this difference was not statistically significant (p=0.78). For all secondary efficacy parameter results were similar. -

Conclusions: This study showed that MEBO ointment for topical treatment of burn injuries presents an attractive alternative for the topical treatment of limited partial thickness thermal burns.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Anti-Infective Agents, Local / administration & dosage*
  • Bandages
  • Burns / drug therapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Ointments / administration & dosage*
  • Pain Threshold / drug effects
  • Severity of Illness Index
  • Silver Sulfadiazine / administration & dosage*
  • Treatment Outcome
  • Water / metabolism
  • Wound Healing / drug effects
  • Young Adult


  • Anti-Infective Agents, Local
  • Ointments
  • Water
  • Silver Sulfadiazine