Building a knowledge base for systems pathology

Brief Bioinform. 2008 Nov;9(6):518-31. doi: 10.1093/bib/bbn038. Epub 2008 Dec 10.


Translating the exponentially growing amount of omics data into knowledge usable for a personalized medicine approach poses a formidable challenge. In this article-taking diabetes as a use case-we present strategies for developing data repositories into computer-accessible knowledge sources that can be used for a systemic view on the molecular causes of diseases, thus laying the foundation for systems pathology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Database Management Systems
  • Databases, Factual*
  • Diabetes Mellitus / genetics
  • Diabetes Mellitus / pathology
  • Diabetes Mellitus / physiopathology
  • Gene Regulatory Networks
  • Humans
  • Information Storage and Retrieval*
  • Information Systems
  • Knowledge Bases*
  • Semantics
  • Signal Transduction / physiology
  • User-Computer Interface