Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Mar;32(3):421-3.
doi: 10.2337/dc08-1161. Epub 2008 Dec 10.

Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes: the Whitehall II study

Christian Herder  1 , Eric J Brunner, Wolfgang Rathmann, Klaus Strassburger, Adam G Tabák, Nanette C Schloot, Daniel R Witte
Affiliations

Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes: the Whitehall II study

Christian Herder et al. Diabetes Care. 2009 Mar.

Abstract

Objective: Interleukin-1 receptor antagonist (IL-1Ra), a natural inhibitor of interleukin-1 beta, has been shown to improve beta-cell function and glycemic control in patients with type 2 diabetes. The aim of this study was to investigate whether baseline systemic levels of IL-1Ra are associated with incident type 2 diabetes during more than 10 years of follow-up.

Research design and methods: We measured serum IL-1Ra concentrations in a nested case-control study (181 case and 376 age-, sex-, and BMI-matched normoglycemic control subjects) within the Whitehall II cohort (U.K.).

Results: IL-1Ra concentrations were higher in case subjects (P = 0.0006) and associated with incident type 2 diabetes (odds ratio for a 1-SD increase of IL-1Ra 1.48 [95% CI 1.21-1.80]). This association remained significant after adjustment for multiple potential confounders but was attenuated by adjusting for 2-h glucose.

Conclusions: Our findings indicate that individuals who will develop type 2 diabetes are characterized by a complex immune activation that also includes upregulation of the anti-inflammatory cytokine IL-1Ra.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Kolb H, Mandrup-Poulsen T: An immune origin of type 2 diabetes? Diabetologia 48:1038–1050, 2005 - PubMed
    1. Herder C, Baumert J, Thorand B, Koenig W, de Jager W, Meisinger C, Illig T, Martin S, Kolb H: Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg Study, 1984–2002. Diabetologia 49:921–929, 2006 - PubMed
    1. Herder C, Klopp N, Baumert J, Müller M, Khuseyinova N, Meisinger C, Martin S, Illig T, Koenig W, Thorand B: Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg Case-Cohort Study, 1984–2002. Diabetologia 51:276–284, 2008 - PubMed
    1. Sell H, Dietze-Schroeder D, Eckel J: The adipocyte-myocyte axis in insulin resistance. Trends Endocrinol Metab 17:416–422, 2006 - PubMed
    1. Donath MY, Schumann DM, Faulenbach M, Ellingsgaard H, Perren A, Ehses JA: Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Diabetes Care 31(Suppl. 2):S161–S164, 2008 - PubMed

Publication types

Substances