The predictive brain state: asynchrony in disorders of attention?

Neuroscientist. 2009 Jun;15(3):232-42. doi: 10.1177/1073858408326429. Epub 2008 Dec 12.


It is postulated that a key function of attention in goal-oriented behavior is to reduce performance variability by generating anticipatory neural activity that can be synchronized with expected sensory information. A network encompassing the prefrontal cortex, parietal lobe, and cerebellum may be critical in the maintenance and timing of such predictive neural activity. Dysfunction of this temporal process may constitute a fundamental defect in attention, causing working memory problems, distractibility, and decreased awareness.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Attention / physiology*
  • Attention Deficit Disorder with Hyperactivity / pathology*
  • Brain / pathology*
  • Brain / physiopathology*
  • Brain Mapping
  • Humans
  • Memory, Short-Term / physiology
  • Neural Pathways / physiopathology
  • Signal Detection, Psychological / physiology